Drug stability measures the in vitro metabolism of therapeutics by liver microsomes, S9 fractions or hepatocyte cultures. Similar tests from intestine, kidney and other organs may also be used. Extensive in vitro metabolism predicts a limited systemic bioavailability in vivo.
Cytoscient offers drug stability assay services on individual drugs or on screening libraries. Metabolism is measured as the decrease in parent drug concentration as quantified using LC/MS/MS. Half-life (T1/2) and Intrinsic clearance (CLint) can be calculated using data from multiple time points.
cytoscient.com 