Transporter inhibition studies use MDCK cells engineered to overexpress individual transporters, together with a corresponding specific substrate. Transporters are membrane proteins crucial for the transfer of drugs across cell membranes. Significant transport inhibition of one drug by a test drug suggests a drug-drug interaction.
Cytoscient offers transporter inhibition studies in cells engineered with a wide range of transporters, including MDR1, BCRP, and others.
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