Preclinical, Clinical and Regulatory Consulting

Drug candidate selection and preparation for clinical testing requires that a comprehensive package…

PK bioanalysis

PK bioanalysis quantifies the concentration of a therapeutic in the body. This information…

Drug stability measures the in vitro metabolism of therapeutics by liver microsomes, S9…

Metabolite profiling identifies the molecular masses of the modified or breakdown products derived…

Drug cell permeability is measured using cell cultures grown in special plates that…

Reaction phenotyping identifies the specific enzymes in the metabolism of drug candidates, which…

Cytochrome P450 inhibition caused by drugs is detected in biochemical or hepatocyte cell…

Non-CYP inhibition caused by drugs should be tested to predict possible drug-drug interactions….

Cytochrome P450 induction caused by a therapeutic is measured in human hepatocyte cultures…

Transporter inhibition studies use MDCK cells engineered to overexpress individual transporters, together with…

Drug protein binding is measured using equilibrium dialysis chambers that separate plasma and…

Drug solubility is measured in solutions that mimic the stomach, intestines, plasma, or…

Drug lipophilicity is determined by measuring the distribution coefficient (LogD) in octanol/water for…

Cytotoxicity of a drug can be measured by the production of death markers…

Phototoxicity of a drug is detected when it sensitizes cultured cells to UV…